Giuliana Rancic Explains Her Skinny Look, Reveals Struggles to Have a Second Baby

Talks have been buzzing for a while, and finally TV host Giuliana Rancic, 40, has spoken out.

People who watched her on the E! coverage of the Golden Globes last Jan. 11 noticed her very thin appearance and have been speculating since then on the reason for her almost emaciated look.

In fact, people have been speculating on Rancic's very slim physique even before the Golden Globes since she is seen almost daily on TV as she goes about her E! hosting duties. The rumors flying around are either she has an eating disorder or, worse, her cancer affliction has come back. Rancic underwent a double mastectomy in 2011 when she was diagnosed with breast cancer.

"Some people were saying, 'The cancer is probably back,' Rancic told People magazine. "And they were accusing me of every eating disorder. I thought to myself, 'God, if someone really said that I had an eating disorder, what a horrible way to approach it.'''

Rancic affirmed that she is healthy although she admitted that the cancer suppressing medication that she has been taking since 2012 has had an effect on her body.

"I started noticing that I was eating a lot, but not gaining weight at all," Rancic said. "I was concerned."

Dr. Dev Paul, her oncologist at Rocky Mountain Cancer Center in Denver, Colorado, had informed her that the drug he prescribed her to alter her metabolism in order to suppress cancer could cause weight loss.

"It's really hurtful," said Rancic of the criticisms about her appearance. She wished the rumors about her would die down on their own. "I'm sorry that some people think I'm disgustingly skinny, as they put it, but there's nothing I can do. I'm lucky that I even have the type of cancer that reacts to the medicine."

Concerning her appetite, she said, "I eat more than any of my friends. I eat a very robust, healthy, balanced diet and dessert almost every night. I'm not hiding from anything."

Rancic's memoir, "Going Off Script," will be released on April 7. In the book, she related her struggles to give her two-year-old son, Duke, a sibling. Because of the risks associated with the medication she's on, pregnancy could be dangerous for her. She and her husband Bill Rancic thus enlisted the help of a surrogate to carry their second baby, as she did with Duke.

The results, however, were not positive. Last New Year's Eve, they learned that the surrogate had miscarried their final embryo. Their surrogate also miscarried in 2014.

"It was painful," she told People. "We were so optimistic with this last embryo. We thought, 'This is definitely going to work. This is our last shot.'"

Rancic said they are now considering adoption as an option.