'Grey's Anatomy' Season 11 Spoilers, Plot News: Jackson And April Will 'Struggle' With Baby's Disease In Winter Premiere

"Grey's Anatomy" returns for its 11th season that would surely leave its fans shivering in a seriously emotional winter on Thursday, Jan. 29.

Actresses Jessica Capshaw and Camilla Luddington advised followers of the hit medical drama series to stock up on tissues and wine when they tune at 8 p.m. every Thursday on ABC.

"There's such huge stuff coming! And it's so top secret we can't even tell you who it involves," Capshaw teased during an interview with TVLine, according to International Business Times.

"At the table read, people were crying. ... There's no relaxing. There's no calm before the storm. It's just storm. All storm, all the time," Luddinton said of the whirlwind of drama set to hit TV screens.

The weepy scenario started off as Jackson, portrayed by Jesse Williams and April, played by Sarah Drew, had to deal with their unborn baby's life-threatening disease.

It was revealed that the baby has osteogenesis imperfecta, or brittle bone disease.

Dr. Herman (played by Geena Davis) explained to Stephanie (played by Jerrika Hinton) that babies born with the brittle bone disease "usually don't live more than a couple of days or weeks."

As if the scene wasn't heartbreaking enough, the winter finale concluded with Jackson confronting Stephanie about the grim topic he overheard concerning his son.

According to Shonda Rhimes, the creator of the medical drama, confirmed the midseason premiere sob-fest will focus on the baby.

"For Jackson, who is a man of science, and April, who is a doctor filled with faith, it is going to be a very interesting struggle," Rhimes revealed to TVLine.

Rhimes added that the show will have a "powerful plot," which will be aired on the ninth episode of the newest season.

She described the plot as really, really beautiful since it involves a character with strong religious faith who fully understands the medical side and the religious aspect of taking care of a baby suffering from a life-threatening disease.

"I've seen doctors on television wrestling with their religious faith in other ways, but this was a really unique one. The way it's handled, the way she handles it, the way her character comes through it is quite beautiful actually. I'm actually really proud of how we told the story," Rhimes said in an interview, according to the Entertainment Weekly.

But don't worry if "Grey's Anatomy" Season 11 will only be just about tear-jerking storylines.

To give the ladies a break from too much emotional scenes, Rhimes assured they will bringing some more men!

"I'm not saying that these new doctors are going to be new series regulars. I'm just saying we need an infusion of men. Suddenly I was like, "We have a lot of chicks and don't have anybody to date," she said.

"Grey's Anatomy" Season 11 aired its first episode on Thursday.